Description
Product Characteristics:
Aliases: EP 4 antibody, EP4 antibody, EP4R antibody, MGC126583 antibody, PE2R4_HUMAN antibody, PGE receptor EP4 subtype antibody, PGE2 receptor EP4 subtype antibody, Prostaglandin E receptor 4 antibody, Prostaglandin E receptor 4 subtype EP4 antibody, Prostaglandin E2 receptor antibody, Prostaglandin E2 receptor EP4 subtype antibody, Prostanoid EP4 receptor antibody, PTGER 2 antibody, PTGER 4 antibody, PTGER2 antibody, PTGER4 antibody
Target Information: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]